"Our study demonstrates that artificial intelligence can identify those asymptomatic people who may harbor an occult cancer at a stage when surgical cure may be possible," says Dr. Goenka. "These findings may help overcome one of the key barriers to improving survival for patients with pancreatic cancer."
Dr. Goenka says a large prospective clinical trial — the Early Detection Initiative (NCT04662879) sponsored by the Pancreatic Cancer Action Network — is underway to evaluate the impact of a pancreatic cancer screening strategy using CTs in 12,500 participants. The trial is being led by Suresh Chari, M.D., an emeritus Mayo Clinic gastroenterologist. Dr. Goenka’s team is exploring the option of prospective validation of their AI models on the CTs to be done as part of the EDI trial.
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Co-authors are Dr. Mukherjee, Panagiotis Korfiatis, Ph.D., Garima Suman, M.D., Shounak Majumder, M.D., Matthew P. Johnson, Nicholas Larson, Ph.D., Darryl Wright, Ph.D., Timothy Kline, Ph.D., Joel G. Fletcher, M.D., and Dr. Chari, all of Mayo Clinic; as well as Anurima Patra, M.D., Hala Khasawneh, M.D., Naveen Rajamohan, M.D., and Ananya Panda, M.B.B.S., who were at Mayo Clinic at the time of this research.
The authors gratefully acknowledge funding from the Centene Charitable Foundation, Champions for Hope Pancreatic Cancer Research Program of the Funk Zitiello Foundation, and the National Cancer Institute.
About Mayo Clinic Comprehensive Cancer Center
Designated as a comprehensive cancer center by the National Cancer Institute, Mayo Clinic Comprehensive Cancer Center is defining new boundaries in possibility, focusing on patient-centered care, developing novel treatments, training future generations of cancer experts, and bringing cancer research to communities. At Mayo Clinic Comprehensive Cancer Center, a culture of innovation and collaboration is driving research breakthroughs that are changing approaches to cancer prevention, screening and treatment, and improving the lives of cancer survivors.
About Mayo Clinic
Mayo Clinic is a nonprofit organization committed to innovation in clinical practice, education and research, and providing compassion, expertise and answers to everyone who needs healing. Visit the Mayo Clinic News Network for additional Mayo Clinic news.
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