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Molecular Imaging Homepage

Subtle Medical closes RSNA with CE mark and FDA clearance of PET AI solution Speeds up scans by factor of four, enhanced image quality

Siemens unveils syngo Virtual Cockpit software for CT, MR and PET at RSNA Offers remote expert technicians when needed

Total-body PET scanner produces landmark human images First ever simultaneously captured 3-D image of the entire human body

South African NTP Radioisotopes facility reopens following year-long closure Will help alleviate worldwide shortages of Mo-99 and other isotopes

TeamBest companies to acquire ABT Molecular Imaging, launch Best ABT Bringing greater expertise to smaller cyclotron technology

Dr. Bernhard Sixt Edinburgh Molecular Imaging appoints as new Chief Executive Officer

Missouri reactor becomes sole US domestic source of I-131 A vital radioisotope in the fight against thyroid cancer and hyperthyroidism

Cardinal Health to distribute IRE ELiT's 68-Ga generators Aiming to alleviate access shortages with Galli Eo generators

Zionexa partners with Columbia PET Center on development of EstroTep Identifies estrogen receptor status to diagnose metastatic breast cancer

Canada to build medical isotope research and development center Will act as a regional source for isotopes, including Tc-99m

Radiolabeled small molecules bind to
fibroblast activation proteins in
cancer-associated fibroblasts found
within the tumor stroma

New PET imaging method may yield benefits over FDG for detecting certain cancers

par Lauren Dubinsky , Senior Reporter
German researchers have developed a PET imaging method that may raise the bar on diagnosing certain cancers.

The method targets cancer-associated fibroblasts (CAFs), which have been linked to tumor growth and are present in over 90 percent of epithelial carcinomas such as pancreatic, colon and breast cancer. The team created a PET tracer based on a FAP-specific enzyme inhibitor (FAPI).

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For a study recently published in the Journal of Nuclear Medicine, they tested the gallium-68-labeled FAPI tracer and a 18F-FDG PET tracer in mouse models as well as a proof-of-concept PET/CT study that involved three patients.

“The competing tracer is FDG, which is hard to beat,” Dr. Uwe Haberkorn of the University Hospital of Heidelberg, told HCB News. “However, we think that due to the high contrast [of] FAPI, [it] may be superior in peritonitis carcinomatosa, liver tumors/metastases, brain metastases, carcinoma of unknown primary, staging of breast cancer and head and neck cancer.”

The study results demonstrated that gallium-68-labeled FAPI has high tumor uptake and clears from the body at a fast rate. That means it generates high-contrast images and has a low chance of binding to healthy tissue in both animals and patients.

According to Haberkorn, issues arise when using 18F-FDG PET to diagnose lung cancer because inflammatory lymph nodes result in false positives. He believes gallium-68-labeled FAPI could be used instead.

“Besides cancer, FAPI may also be used for benign diseases with remodelons such as fibroses, artherosclerosis, rheumatoid arthritis, sarcoidosis, etc.,” he added.

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