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Molecular Imaging Homepage

GE to provide training to at least 140 Kenyan radiographers Partnering with Society of Radiography in Kenya

NorthStar, Shine in line for federal funding Bringing $20 million in additional funding to domestic moly-99 in the US

Adel Abdullah and Aaron Hargrave Positron appoints president and vice president

Theranostics – Nuclear medicine´s fountain of youth Combining therapeutics with diagnostics, opportunities and challenges

New House bill calls for change in CMS definition of radiopharmaceuticals Reimburse separately instead of as bundled payment

Cerveau Technologies partners with Ionis Pharmaceuticals Use of PET agent, [F-18]MK-6240

Dr. David Wong Professor recognized for contributions to PET and Theranostics

SVSR unveils Siemens Horizon PET/CT trailer Putting a small and powerful scanner on a coach

Philips to manage medical imaging equipment for Aussie providers for 20 years First-of-its-kind partnership in Australia and ASEAN Pacific region

Under AMG, Piramal Imaging changes name to Life Molecular Imaging LMI is being run within the Alliance Medical Molecular Imaging division

Radiolabeled small molecules bind to
fibroblast activation proteins in
cancer-associated fibroblasts found
within the tumor stroma

New PET imaging method may yield benefits over FDG for detecting certain cancers

par Lauren Dubinsky , Senior Reporter
German researchers have developed a PET imaging method that may raise the bar on diagnosing certain cancers.

The method targets cancer-associated fibroblasts (CAFs), which have been linked to tumor growth and are present in over 90 percent of epithelial carcinomas such as pancreatic, colon and breast cancer. The team created a PET tracer based on a FAP-specific enzyme inhibitor (FAPI).

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For a study recently published in the Journal of Nuclear Medicine, they tested the gallium-68-labeled FAPI tracer and a 18F-FDG PET tracer in mouse models as well as a proof-of-concept PET/CT study that involved three patients.

“The competing tracer is FDG, which is hard to beat,” Dr. Uwe Haberkorn of the University Hospital of Heidelberg, told HCB News. “However, we think that due to the high contrast [of] FAPI, [it] may be superior in peritonitis carcinomatosa, liver tumors/metastases, brain metastases, carcinoma of unknown primary, staging of breast cancer and head and neck cancer.”

The study results demonstrated that gallium-68-labeled FAPI has high tumor uptake and clears from the body at a fast rate. That means it generates high-contrast images and has a low chance of binding to healthy tissue in both animals and patients.

According to Haberkorn, issues arise when using 18F-FDG PET to diagnose lung cancer because inflammatory lymph nodes result in false positives. He believes gallium-68-labeled FAPI could be used instead.

“Besides cancer, FAPI may also be used for benign diseases with remodelons such as fibroses, artherosclerosis, rheumatoid arthritis, sarcoidosis, etc.,” he added.

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