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Radiology study seeks fuller picture of 'incidentalomas'

Press releases may be edited for formatting or style | May 11, 2021 CT X-Ray
Say you get a CT scan to confirm whether your chest pain is from a fractured rib. You learn a few days later that no bone break was detected – yay! – but joy gives way to anxiety as you read the radiologist’s note, from the same scan, of a spot in one of your lungs.

With advances in medical imaging and our aging population, such findings are increasingly common. Doctors call them “incidentalomas.” Although in most cases the attendant risk is low, sometimes they represent very early cancers. Patients can, of course, be consumed with dread at the suggestion of cancer and the financial hit of recommended follow-up scans and biopsies.

“These apparent cancers have a wide spectrum of appearances. When we identify them, we usually don’t know whether they represent a cancer or whether there is short- or long-term risk,” said Dr. Martin Gunn, a professor of radiology at the University of Washington School of Medicine. “We usually recommend follow-up with advanced imaging like ultrasound, CT, MRI, or nuclear medicine to find out and to ensure it does not grow.”

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Gunn will co-lead a just-funded study of incidental findings to shed light on which patients and imaging findings put patients at the highest and lowest risk of adverse outcomes. He’ll work with Meliha Yetigsen, UW associate professor of biomedical informatics.

The project will analyze 4 million radiology reports to gauge incidentalomas’ impact on morbidity, mortality, and the cost-effectiveness of recommended imaging surveillance and intervention.

The researchers will examine the six most frequently detected incidental lesions: in the lung, liver, kidney, pancreas, adrenal gland, and thyroid gland. They will develop a database of individual records detailing the follow-up costs involved, and ultimate result – a benign or cancerous finding, a “lost” case in which the patient does not return for subsequent care, and whether the incidentaloma resulted in poor health outcomes. Each record would also identify comorbidities and demographic info that might lend insight to risk factors and social determinants of the patient’s long-term health, Gunn said.

“If we look at lung nodules, in the low-risk person with an incidental nodule of less than 6 millimeters, the risk of that being cancer is less than 1%. In that setting we’d only recommend follow-up if the patient has a strong smoking history. At the other end of the spectrum, if the lung nodule is more than 1 centimeter, the cancer risk is substantially higher,” Gunn said. “So we’re hoping to better identify which cases are most appropriate to follow up, and what’s the best way to do that.”

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