DOTmed Home MRI Oncology Ultrasound Molecular Imaging X-Ray Cardiology Health IT Business Affairs
News Home Parts & Service Operating Room CT Women's Health Proton Therapy Endoscopy HTMs Pediatrics
Endroit courant :
> This Story

starstarstarstarstar (1)
Ouverture ou Registre to rate this News Story
Forward Printable StoryPrint Comment




More Magazine Features

Theranostics continue to gain momentum Investments ramp up but challenges remain

In nuclear medicine, scanners get more sensitive, software more specific What's new in PET and SPECT?

Installing and removing imaging equipment is no small task Expert insights on how project management is evolving

Informatics, standardization and the next phase for enterprise imaging Life after silos is coming into focus

Assessing the state of Alzheimer’s imaging The battle against neuro-degenerative disease wages on

See All Magazine Features  

Ultrasound Homepage

Hologic puts forth $85 million offer to buy SuperSonic Imagine An entry into cart-based breast ultrasound market

MR and ultrasound biopsies combined can detect prostate cancers, says study Detect up to 33 percent more tumors together

Fujifilm SonoSite brings new workflow solution to point of care ultrasound Addressing top priorities to reduce administrative burden on providers

New dye helps control 'lighting' for sharper images of heart May help identify early signs of heart disease

Ultrasound market gets supercharged by AI, cloud, and greater portability: report Generated $6.12 billion in 2018, and more growth expected

Verasonics settles legal dispute over software with SuperSonic Imagine Alleged patent infringement and misappropriate of trade secrets

Handheld ultrasound market poised for next wave of growth Insights from the market analysts at Signify Research

VisualDx to develop decision support platform for ultrasound in space Provide basic guidance on ultrasound interpretation

Purchasing insights for cardiac ultrasound Guidance from the market experts at MD Buyline

Trice Imaging connects imaging devices of large chain healthcare provider Aleris Patients and physicians can view images on laptops, cell phones

Breaking barriers in Alzheimer’s disease with focused ultrasound

From the April 2019 issue of DOTmed HealthCare Business News magazine

By Ying Meng and Nir Lipsman

Few among us have been untouched in some way by Alzheimer’s disease (AD).
Whether a parent or grandparent, in the clinic or at home, the challenges of the disease and the toll it takes on patients and their families is significant, and only expected to grow. According to recent statistics from the United States, AD is the only top 10 cause of death that cannot be prevented, cured or slowed. Such sobering facts highlight that despite significant advances in our understanding of its pathophysiology, genetics and brain imaging, we are still far from effective disease-modifying therapies.

However, as we look to the future, novel treatments, such as focused ultrasound (FUS), continue to be investigated as technology that may one day help close this “therapeutic gap”. FUS uses the power of ultrasound waves to influence pathways deep inside the brain without needing traditional surgery or scalpels.
Story Continues Below Advertisement

RaySafe helps you avoid unnecessary radiation

RaySafe solutions are designed to minimize the need for user interaction, bringing unprecedented simplicity & usability to the X-ray room. We're committed to establishing a radiation safety culture wherever technicians & medical staff encounter radiation.

Barriers to progress
The challenges of therapeutic development in AD are many, and range from our evolving understanding of its pathology, to designing clinical trials, detecting the disease at an early stage, and defining meaningful outcomes. Recognized now for decades as being, perhaps, the largest challenge: the blood brain barrier (BBB). The BBB is a feature unique to the central nervous system, and is a physical barrier, composed of tightly bound cells and processes that line the surface of fine capillaries within the brain. The BBB restricts the passage of large molecules, including potential therapeutics, into the brain, and expels certain drugs that do make it past the BBB. In cases where therapeutics do cross, failure to do so efficiently or at clinically meaningful concentrations is an important reason for poor treatment responses. In conjunction with developing targeted and effective pharmaceutical options, there is an urgent need to develop ways to enhance their delivery across the BBB, to where they are needed most, directly at the site of pathology.

Promising science
Safely and effectively overcoming the BBB has been a target of researchers for decades. To date, most attempts have required an operation, inserting catheters into the brain and infusing agents at high concentrations, as a way to “overwhelm” the barrier. Researchers at Sunnybrook Health Sciences Centre in Toronto, Canada have developed an entirely different approach, utilizing low-frequency focused ultrasound, that is noninvasive, does not require surgery or implants, and that is able to open the BBB quickly, safely and reversibly. Pioneered by Dr. Kullervo Hynynen, at Sunnybrook, this technology takes advantage of the oscillation of preformed inert microbubbles, which, when exposed to ultrasound rapidly oscillate, and cause a physical opening in the BBB that is temporary. Focused ultrasound circumvents many of the challenges of previous BBB technology, as it is image-guided, occurs in real-time, and leads to closure of the BBB within hours of the procedure.
  Pages: 1 - 2 - 3 >>

Ultrasound Homepage

You Must Be Logged In To Post A Comment

La publicité d'email
Développez la notoriété de votre marque
Enchères + Ventes Privées
Obtenir le meilleur prix
Acheter des équipement / pièces
Trouver le meilleur prix
Infos du jour
Lire Les dernières nouvelles
Consulter tous les utilisateurs DOTmed
Éthique concernant DOTmed
Voir notre programme d'éthique
L'or partie le programme de fournisseur
Recevoir des demandes PH
Programme de marchand de service d'or
Recevoir des demandes
Fournisseurs de soins de santé
Voir tous les outils des HCP (abréviation pour les professionnels de la santé)
Trouver / combler un poste
Parts Hunter +EasyPay
Obtenir des devis de pièces
Voir les utilisateurs récemment certifiés
Voir les utilisateurs récemment certifiés
Récemment évalué sur DOTmed
Voir les utilisateurs récemment certifiés
Central de location
Louer de l’équipement à moindre prix
Vendre des équipements / pièces
Obtenir le maximum d'argent
Service Technicians Forum
Trouver de l'aide et des conseils
Simple demande de propositions
Obtenir des devis pour des appareils
Expo Virtuelle
Trouver des services d'appareils
L'Access et l'utilisation de cet emplacement est sujet aux modalités et aux conditions du notre de nos MENTIONS LEGALES & DONNEES PERSONELLES
Propriété de et classe des propriétaires DOTmedà .com, inc. Copyright ©2001-2019, Inc.