"Our study takes advantage of the rich expertise of our cross-disciplinary team and uses chemistry, biochemistry, genetics in diverse biomedical technologies on suitable disease models, which has resulted in the discovery of a PET tracer that will open new avenues for us to better understand the complex puzzle and facilitate drug discovery in AD," says Yulong Xu, PhD, investigagor in the Martinos Center and first author of the study.

Wang adds that "our study provides a great example of our effort in developing aging-related probes; additionally, this probe can be used, in combination with our RIPK1 and SIRT1-based novel probes currently under development, to provide a comprehensive and unprecedented level of knowledge in not only AD, but also other aging-related neurodegenerative disorders."

About the Massachusetts General Hospital
Massachusetts General Hospital, founded in 1811, is the original and largest teaching hospital of Harvard Medical School. The MGH Research Institute conducts the largest hospital-based research program in the nation, with an annual research budget of more than $1 billion and comprises more than 8,500 researchers working across more than 30 institutes, centers and departments. In August 2020 the MGH was named #6 in the nation by U.S. News & World Report in its list of "America's Best Hospitals."

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