Ghoraani and collaborators from the Rochester Institute of Technology, the University of Rochester Medical Center, and SUNY Upstate Medical Center, tested ICAN on realistic simulated data with several test cases of rotor and foci-driven arrhythmias, which covered a broad range of activation patterns in 2D as well as 3D AFib simulations. They placed the catheter on 114,921 initial catheter locations across the simulated region for different rotor and foci mechanisms. In all cases, they modeled globally distributed fibrosis.
"Professor Ghoraani and her collaborators have developed a cutting-edge technique that has the potential to be a game-changer in how electrophysiologists treat atrial fibrillation with ablation," said Stella Batalama, Ph.D., dean of FAU's College of Engineering and Computer Science. "The high performance of this algorithm is evident by the high source detection success rate. ICAN could significantly improve the success of patient-specific atrial fibrillation ablation and facilitate treating patients before the disease progresses to the permanent stage."
In addition, the researchers have demonstrated the feasibility of their study in a few human clinical Afib cases and plan to further validate ICAN in more patients. There are currently two patents pending for certain aspects of the algorithm.
Co-authors of the study are Prasanth Gaensan, a graduate student in FAU's College of Engineering and Computer Science; Elizabeth M. Cherry, Ph.D., Rochester Institute of Technology; David T. Huang, M.D., University of Rochester Medical Center; and Arkady M. Pertsov, Ph.D., SUNY Upstate Medical University.
About FAU's College of Engineering and Computer Science:
Florida Atlantic University's College of Engineering and Computer Science is committed to providing accessible and responsive programs of education and research recognized nationally for their high quality. Course offerings are presented on-campus, off-campus, and through distance learning in bioengineering, civil engineering, computer engineering, computer science, electrical engineering, environmental engineering, geomatics engineering, mechanical engineering and ocean engineering.
About Florida Atlantic University:
Florida Atlantic University, established in 1961, officially opened its doors in 1964 as the fifth public university in Florida. Today, the University, with an annual economic impact of $6.3 billion, serves more than 30,000 undergraduate and graduate students at sites throughout its six-county service region in southeast Florida. FAU's world-class teaching and research faculty serves students through 10 colleges: the Dorothy F. Schmidt College of Arts and Letters, the College of Business, the College for Design and Social Inquiry, the College of Education, the College of Engineering and Computer Science, the Graduate College, the Harriet L. Wilkes Honors College, the Charles E. Schmidt College of Medicine, the Christine E. Lynn College of Nursing and the Charles E. Schmidt College of Science. FAU is ranked as a High Research Activity institution by the Carnegie Foundation for the Advancement of Teaching. The University is placing special focus on the rapid development of critical areas that form the basis of its strategic plan: Healthy aging, biotech, coastal and marine issues, neuroscience, regenerative medicine, informatics, lifespan and the environment. These areas provide opportunities for faculty and students to build upon FAU's existing strengths in research and scholarship.
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