"We wanted to investigate the efficacy of fusion biopsy in comparison to systematic biopsy in the detection of clinically significant prostate cancer and to determine the effect the number of prior negative biopsies had on cancer detection with each method," he says.
The cases of 779 patients--each with a history of one or more negative biopsies who also underwent MRI biopsy fusion--from four institutions were analyzed making it one of the largest studies in this population, says Sidana. Institutions included the National Cancer Institute in Maryland; Northwell Health in New York; University of Alabama at Birmingham School of Medicine; and State University of New York Upstate Medical University.
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The average age of patients was 63. Of the 779 patients, cancer was detected in 346 patients (44 percent), and the clinically significant cancer detection rate was 30.7 percent with fusion biopsy detecting 26.3 percent (205 cases) and systematic biopsy detecting only 4.4 percent (34 cases).
"Of all cancers detected by each method, fusion biopsy detected a higher proportion of clinically significant cancer when compared to standard biopsy," Sidana adds. "Fusion biopsy also outperformed standard biopsy in finding high-risk prostate cancer. While patients with a higher number of prior prostate biopsies had a poorer cancer detection rate on standard prostate biopsy, detection on fusion biopsy stayed constant and did not decrease in patients with a higher number of prior prostate biopsies, thus proving it to be more accurate in finding cancers."
Sidana says these results show that the fusion biopsy technique should be used in patients with suspicion of prostate cancer.
"These findings may work to change or improve standard of care and could help in avoiding unnecessary biopsies, saving patients and health care systems money, as well as helping to diagnose cancers earlier, improving patient care and quality of life," he says.
This study was supported by an intramural research program of the National Institutes of Health. Authors cite no conflict of interest.
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